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Carcinogenesis 24, —6 Download references. You can also search for this author in PubMed Google Scholar. All the authors reviewed the manuscript. Reprints and Permissions. Marahatta, A. Soybean greatly reduces valproic acid plasma concentrations: A food—drug interaction study. Sci Rep 4, Download citation. Received : 12 November Accepted : 25 February Published : 12 March Anyone you share the following link with will be able to read this content:.
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Neurological Sciences Nature Communications European Journal of Clinical Pharmacology By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Advanced search. Skip to main content Thank you for visiting nature. Download PDF. Subjects Clinical pharmacology Drug safety. Abstract The aim of this study was to investigate the effects of soy on the pharmacokinetics and pharmacodynamics of valproic acid VPA.
Introduction Valproic acid 2-propylvaleric acid VPA is an antiepileptic drug that enhances aminobutyric acid transmission 1 in the central nervous system. Table 1 Pharmacokinetic data of valproic acid Full size table. Figure 1. Soy inhibits the plasma concentration of valproic acid. Full size image. Figure 2. Figure 3. Induction of UGT enzymes in soy pretreated rats compared to untreated. Figure 4. Measurement of glucuronidation enzyme activity. Figure 5. Discussion When patients are prescribed a drug with a narrow therapeutic margin or are suffering from a specific pathological condition such as liver malfunction, food drug interactions may be an important issue for the patient's health.
Preparation of soy extract Soybeans were purchased from a local Jeonju market South Korea. Blood and urine sampling Blood samples were collected at the following time points: 0, 0. Quantification of GABA Brains were removed, weighed, dissected and homogenized in trichloroacetic acid. Microsome preparation Hepatic microsomes were prepared as described previously by Lee et al Pharmacokinetic analysis The pharmacokinetic profiles of VPA were obtained by non-compartmental analysis using WinNonlin version 5.
References Czuczwar, S. View author publications. Ethics declarations Competing interests The authors declare no competing financial interests. Electronic supplementary material.
Supplementary Information Supplementary Data. About this article Cite this article Marahatta, A. Copy to clipboard. Comments By submitting a comment you agree to abide by our Terms and Community Guidelines. Publish with us For authors Submit manuscript. Valproic acid is also used to treat the manic phase of bipolar disorder manic-depressive illness , and helps prevent migraine headaches. There is a problem with information submitted for this request.
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You may opt-out of e-mail communications at any time by clicking on the Unsubscribe link in the e-mail. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture not in the bathroom.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at If you are taking the sprinkle capsules, you may notice the medication beads in your stool. This is normal and does not mean that you did not get the full dose of medication.
If you have diabetes and your doctor has told you to test your urine for ketones, tell the doctor that you are taking valproic acid. Valproic acid can cause false results on urine tests for ketones. Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking valproic acid. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. Valproic Acid pronounced as val proe' ik. Why is this medication prescribed?
How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names Other names. Do not mix the syrup into any carbonated drink. Your doctor may start you on a low dose of valproic acid and gradually increase your dose.
Other uses for this medicine. What special precautions should I follow? Before taking valproic acid, tell your doctor and pharmacist if you are allergic to valproic acid, any other medications, or any of the ingredients in the type of valproic acid that has been prescribed for you. Ask your pharmacist for a list of the ingredients. Be sure to mention any of the following: acyclovir Zovirax , anticoagulants 'blood thinners' such as warfarin Coumadin , amitriptyline, aspirin, carbamazepine Tegretol , cholestyramine Prevalite , clonazepam Klonopin , diazepam Valium , doripenem Doribax , ertapenem Invanz , ethosuximide Zarontin , felbamate Felbatol , certain hormonal contraceptives birth control pills, rings, patches, implants, injections, and intrauterine devices , imipenem and cilastatin Primaxin , lamotrigine Lamictal ,medications for anxiety or mental illness, meropenem Merrem , nortriptyline Pamelor , phenobarbital, phenytoin Dilantin , primidone Mysoline , rifampin Rifadin , rufinamide Banzel , sedatives, sleeping pills, tolbutamide, topiramate Topamax ,tranquilizers,and zidovudine Retrovir.
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Do not drive a car or operate machinery until you know how this medication affects you.
Tell your doctor if you are not able to eat or drink as you normally do.
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